Author: Hartmut Geiger Publisher: Springer ISBN: 370911232X Category : Science Languages : en Pages : 354
Book Description
Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.
Author: K.L. Rudolph Publisher: Karger Medical and Scientific Publishers ISBN: 3318027324 Category : Medical Languages : en Pages : 97
Book Description
The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.
Author: K.L. Rudolph Publisher: Karger Medical and Scientific Publishers ISBN: 3805592442 Category : Medical Languages : en Pages : 116
Book Description
There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field.The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis.Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology.
Author: Surajit Pathak Publisher: Academic Press ISBN: 0128204133 Category : Science Languages : en Pages : 322
Book Description
Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe
Author: Rakesh Sharma Publisher: BoD – Books on Demand ISBN: 1789230101 Category : Science Languages : en Pages : 353
Book Description
Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.
Author: M.P. Mattson Publisher: Elsevier ISBN: 9780444507310 Category : Medical Languages : en Pages : 240
Book Description
The developmental capabilities and therapeutic potential of stem cells are being revealed in studies of cellular signaling mechanisms that regulate their proliferation, differentiation and survival. "Stem Cells: A Cellular Fountain of Youth" reviews the current state of understanding of the molecular mechanisms that regulate embryonic and adult stem cells with an emphasis on how aging and age-related disease impact on these mechanisms. Leading authorities detail the properties and therapeutic potential of embryonic stem cells, and stem cell precursors of blood, nervous and muscle and bone cells. Recent advances in deciphering the environmental signals and intrinsic signal transduction pathways that regulate embryonic stem cells are described, and the potential therapeutic uses of these totipotent cells is considered. Analyses of hematopoietic stem cells during aging suggest an important genetic component to the control of their self-renewing capability which may contribute to determination of lifespan. The contribution of lymphocyte depletion to impaired immune function during aging is considered, as is the potential of hematopoietic cells to form other types of cells including neurons. Several chapters cover the remarkable and rapidly advancing field of neural stem cells. The adult brain contains populations of stem cells capable of forming new neurons and glial cells; the signals that regulate these neural stem cells and the involvement of neurogenesis in normal brain function is described. Because of their potential to replace lost or damaged neurons, there has been intense interest in determining the therapeutic potential of stem cells for the treatment of patients with Parkinson's and Alzheimer's diseases, stroke and traumatic brain and spinal cord injuries. Heart and skeletal muscle contain stem cells and the impact of aging and disease on these stem cell populations and the potential of stem cell therapy to recover function of these organs is reviewed. A final example of the fascinating world of stem cells is a review of the roles of stem cells in bone formation and remodeling. Collectively, this book provides a comprehensive, yet concise, view of stem cell molecular biology in the context of aging and age-related disease. This book will be a valuable reference for graduate students and senior scientists interested in the fascinating world of stem cells and their potential use in the clinic.
Author: K. Lenhard Rudolph Publisher: Karger Medical and Scientific Publishers ISBN: 3318021709 Category : Medical Languages : en Pages : 135
Book Description
Up-to-date meeting report of the Else Kr ner-Fresenius Symposium on Adult Stem Cell Aging Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells. This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kr ner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.
Author: Lauren Kokai Publisher: Academic Press ISBN: 0128193778 Category : Science Languages : en Pages : 486
Book Description
Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications
Author: Masaki Ieda Publisher: Springer ISBN: 3319561065 Category : Medical Languages : en Pages : 274
Book Description
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Author: Hartmut Geiger
Author: K.L. Rudolph
Author: K.L. Rudolph
Author: Surajit Pathak
Author: Yuelin Zhang
Author: Rakesh Sharma
Author: M.P. Mattson
Author: K. Lenhard Rudolph
Author: Lauren Kokai
Author: Masaki Ieda